ASTM F2458 Wound Closure Strength of Tissue Adhesives and Sealants

Mechanical Testing of Bioadhesives

ASTM F2458

ASTM F2458 is a testing standard that specifically focuses on characterizing the wound closure strength of tissue adhesives or sealants. Adhesive wound closure is sometimes preferable to using staples or stitches, as it reduces patient discomfort is and is often more easy to apply. It is extremely important that these products perform as expected, as failure could cause internal or external bleeding and leave a patient vulnerable to infection at the wound site. In order for wounds to heal properly over time and prevent scarring, the adhesive must continue to hold the tissue together until healing occurs.

ASTM F2458 is primarily intended for comparative testing between different adhesive formulations. Identifying a repeatable and life-like substrate enables this standard to be used for quality control purposes of adhesive wound closure products. The test will provide the maximum force at the time of failure as well as the failure mode – typically labelled as adhesive (failure of the adhesive/substrate bond), cohesive (failure of the internal adhesive bond), or substrate failure (failure of the tissue). To read the standard in full, purchase ASTM F2458.

Materials Testing System

For ASTM F2458 testing we recommend a 6800 Series single column testing system with a 100 N load cell and pneumatic grips. Because tissues are typically fragile, they require surfalloy style faces for clamping on the specimen successfully. A flexible coupling is required to ensure the loading is applied through the center of the specimen. For closure devices used internally within the body, the testing should be performed at a temperature of 37 Celsius. A biobox is useful for testing at body temperature.

ASTM F2458 Test Setup
1) 5900 Series Universal Testing System
2) 2530-100 Load Cell
3) Pneumatic Side Action Grips
4) Instron BioBox


ASTM F2458 system setup
Related Content

6800 系列高级测试系统宣传册

Instron 6800 系列通用测试系统可提供无与伦比的准确性和可靠性。6800 系列以专利申请中的操作员保障系统架构为依托,架构采用全新的 Smart-Close 空气套件并具有碰撞缓解功能,使得材料测试比以往任何时候都更简单、更智能、更安全。

Bluehill Universal 宣传册

Bluehill Universal 软件从头开始构建,旨在提供触摸互动和直观的用户体验。使用诸如预装测试方法、几秒钟内快速测试、增强的数据导出以及 Instron Connect(一种全新功能,可提供与服务的直接通信联系)等功能,发现更简单、更智能的测试。 Bluehill 2 和 Bluehill 3 等以前版本软件的用户可以轻松升级到最新版本的 Bluehill。

用于 37°C 医疗器械测试的 BioBox

Instron 的 BioBox 提供可控体温 (37°C) 空气环境,便于对医疗器械和生物材料进行测试。

潜式侧动气动夹具和温控型 BioBath 水浴装置

Instron 的温控型 BioBath 水浴装置可精确模拟生物医学测试所需的环境条件。